IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A novel role for medial prefrontal cortex in taste aversion memory.
Autor/es:
GONZALEZ CM; VILLAR ME; TOMAIOULO M; VIOLA H; MEDINA J H
Lugar:
Milan
Reunión:
Congreso; 9th FENS Forum of Neuroscience, Milan, Italy, July 5-9, 2014.; 2014
Institución organizadora:
FENS
Resumen:
A
novel role for medial prefrontal cortex in taste aversion memory
Gonzalez
C, Villar ME, Tomaiuolo M, Viola H, Medina JH
The role of the medial
prefrontal cortex (mPFC) in taste aversion memory processing has been scarcely
investigated. Few works have studied its participation in conditioned taste
aversion (CTA) extinction memory and only one work described a prefrontal
b-adrenergic receptors requirement in CTA memory formation. Nevertheless, it
has recently been described that mPFC neurons can encode aspects of gustatory
stimuli suggesting that this cortex could be part of the encoding taste
network. In this work, we studied the involvement
of the mPFC in taste memory processing using the CTA task in rats. We
microinfused the protein synthesis inhibitor emetine, the GABAa receptor
agonist muscimol or the N-methyl-d-asparate (NMDA) receptors antagonist AP-V
into the mPFC before CTA training. We found that all these treatments impaired
the formation of CTA long-term memory, but not its acquisition. Furthermore, we
infused muscimol before a 72h-retention test session and observed impairment in
CTA long-term-memory retention. These results indicate that neural activity, protein
synthesis and NMDA receptors in the mPFC are necessary during training or early
after for CTA memory consolidation and that this cortex is required for normal
CTA memory retrieval. Altogether, our findings suggest that the mPFC is an
essential structure taking part in the CTA memory processing network.