IBCN 20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Parkinson?s in a dish: a model to study synuclein overexpression on mitocondrial function using human neurons
Autor/es:
POZO-DEVOTO V; DIMOPOULUS N; ALLOATTI M; SEVLEVER G; FALZONE T
Reunión:
Congreso; XXVIII Congreso de la Sociedad Argentina de Neurociencias; 2013
Institución organizadora:
SAN
Resumen:
The main pathological feature of Parkinson's disease consists in a progressive damage of dopaminergic neurons, caused ?among many others? byalfa-synuclein (aSyn) gene duplication or point substitutions: A30P, A53T and E46K. Growing evidence links mitochondrial disfunction and oxidative stress withParkinson's neuronal loss, however, aSyn direct or indirect interactions with mitochondria remains unknown. As Parkinson?s disease modeling in animals provedifficult, stem cells research development has opened a promising field to study human diseases in human cells. In the present work we analyze the effects of wtor mutant forms (A30P and A53T) of aSyn overexpression in human embryonic stem cells (hESC) derived neurons, focusing on mitochondrial homeostasis anddynamics.
