IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Long-term memory formation of object in context task
Autor/es:
VILLAR, M, EUGENIA; MARTINEZ, MARÍA CECILIA; BALLARINI, FABRICIO; VIOLA, HAYDÉE
Reunión:
Conferencia; Congreso de la Sociedad Argentina de Investigación en Neurociencia; 2013
Resumen:
Long-term memory formation of object in context task requires medial
prefrontal cortex activity and it is interfered by another object in context
experience.
Recognition memory
refers to the ability to identify an object or a situation and judge if it was
previously experienced or not. In particular, the recognition of an item in
connection with a context (what-where) constitutes an important element of
episodic memory, which also implies
remembering about what-when.
Here, we reveal that the acquisition of information about
object-context association put in risk the long-term memory (LTM) expression
for a previously learned associate object-context pair. Also, we investigated the effective temporal window of that
interference, the required features of the interpolated material to be effective,
as well as the brain regions involved in the phenomenon.
Our results show that
LTM formation for a novel object associated with a context (but not the object
recognition LTM) can be impaired if rats are subsequently exposure to a
different object in context experience. Thus, the second learning experience
can exert retrograde interference over the first one, in a limited temporal
window. Finally, our results strongly suggest that the medial prefrontal cortex
and dorsal hippocampus are important brain regions involved in the processing
of both pairs of association and when both of them are being consolidated at
overlapping time course, a competition occurs and only one of them could be
store.