Cannabinoids. neurotoxic and/or neuroprotector?

CALTANA LAURA; SAEZ TRINIDAD; BRUSCO ALICIA

Mexico DF

Congreso; 4th Meeting of the International Drug Abuse Research Society; 2013

International Drug Abuse Research Society

The aim of this work was to analiza two aspects of brain exposition to cannabinoids: 1- the effects on prenatal development of crebral cortx and 2- neuroprotective effects after stoke in adulthood. We evaluated the effects of prenatal exposition to WIN 5,212-22(WIN) in neuronal proliferation, migration and diferentiation during cerebral development. Pregnant Wistar rats were treated fom gestational day 5 to 20 at a daily s.c. dose (0,75 mg/kg of WIN. In particular, glutamatergic neuronal progenie as well as of their transcriptionn factor (Tbr1 and Tbr2) showed changes.  WIN-exposed embryos showed an increased in the number of tangential and radial migrating postmitotic neuroblast and also the number of intermediate progenitors cells and early-postmitotic projection neurons was impared in the developing cortex. Finally,  it was also proved that CB1 knockout mice showed a disminushed number of  intermeditae progenitors and higher number of glutamatergic post-mitotic neurons. During postnatal life, the deletion of rCB1 induced an abnormal distribution of interneurons. These results confirm the role of cannabioid system i the development of the cerebral cortex, and could be explain some adverse consequences of cannabinoid exposition during pregnancy.