IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Memory Traces Compete Under Regimes Of Limited Arc Protein Synthesis: Implications For Memory Interference And Forgetting
Autor/es:
MARTÍNEZ, MARÍA C.; ALEN, NADIA; BALLARINI, FABRICIO; MONCADA, DIEGO
Lugar:
Barcelona
Reunión:
Congreso; 8th FENS forum 2012; 2012
Institución organizadora:
Eurpean Federation for Neurosciences
Resumen:
Recently encoded information can be forgotten
in the presence of new information, a process called 'retrograde interference'. Retrograde interference has been
extensively described for more than a century and it is thought to be one of
the major causes of forgetting. However little is known about its underlying
mechanisms. Different approaches agree on the need of the synthesis of plasticity
related proteins (PRPs) to consolidate a long-term memory. Here, by combining two different learning
tasks in rats (inhibitory avoidance and open field exploration), we demonstrate that memory traces compete for their
stabilization when protein resources are limited. As a result, LTM is formed for
only one of the tasks with the subsequent memory forgetting for the other one.
Furthermore, we found that Arc is necessary for the consolidation of these
memories and is one of the PRPs being disputed between them. In sum, these
findings suggest that under conditions of reduced protein
availability, a
learning task interferes with the consolidation of other learning by winning
over and utilizing the available PRPs.