IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Sonic hedgehog response in photoreceptors in a model of spectral deprivation.
Autor/es:
RONCO, LAURA; BEJARANO, CLAUDIO; FOSSER, NICOLÁS; PAGANELLI, ALEJANDRA
Lugar:
Córdoba
Reunión:
Congreso; XXVI Congreso Anual SAN; 2011
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Sonic hedgehog response in photoreceptors in a model of spectral deprivation
L. Ronco, C, A. Bejarano, N. S. Fosser, H. Ríos and A. R. Paganelli
Inst. de Biol. Cel. y Neurociencias Dr. E. de Robertis. F. Medicina, UBA. Paraguay 2155 (1121). Bs. As. Argentina.
Photoreceptor
cells have a specialized primary cilium called the outer segment (OS).
Mutations that affect OS generally lead to ciliopathies, which include
retinal photoreceptor degeneration. Furthermore, macular degeneration
is associated to ?blue? light exposure, since blue light wavelengths
impart the greatest risk of photochemical damage.
The
morphogen Sonic hedgehog (Shh) is essential for photoreceptor
differentiation and retinal cell survival during embryonic development.
Shh is expressed in the retina during postnatal growth but its
function is unclear. With the aim to analyze the response of Shh by light and its function in the OS, we applied a spectral deprivation model. We found a gradual decrease of Shh protein when chickens were reared with long,
medium or short wavelength lights compared with a white light group.
Our results could indicate progressive retinal cell modifications both
structural and functional in these cells. We suggest that Shh signaling
may be required to maintain photoreceptors viability throughout life and that their levels are in part regulated by light. UBACyT 20020090200198.