IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effects of monochromatic light in the expression patterns of the transcription factors LIM 1+2 and Islet-1 in horizontal neurons
Autor/es:
BEJARANO, CLAUDIO; PAGANELLI, ALEJANDRA; FOSSER, NICOLÁS; RÍOS, HUGO
Lugar:
Córdoba
Reunión:
Congreso; XXVI Congreso Anual SAN; 2011
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Effects of monochromatic light in the expression patterns of the transcription factors LIM 1+2and Islet-1 in horizontal neurons.C.A. Bejarano, A. R. Paganelli, N. S. Fosser y H. RíosInstituto de Biología Celular y Neurociencias Dr. Eduardo de Robertis. Facultad de Medicina,UBA. Paraguay 2155 Piso 3 (1121) Ciudad Autónoma de Buenos Aires. Argentina.Horizontal cells provide the pathways for local and long range interactions betweenphotoreceptors. They are related to lateral inhibition, contrast and color processing. It is knownthat light modifies the intraretinal synaptic connection pattern, however, little or nothing is knownabout how each subtype of horizontal neurons (H1-H4) respond to a particular wavelength.To analyze the effect of spectral deprivation, chickens were reared with cycles of 12 hlight-12 h dark with white or longer (LWL), medium (MWL) or short wavelength light (SWL) for 12days). Retinas were analyzed after labeling with calretinin (CR) and the transcription factors, Islet-1, LIM 1 +2.Animals reared in MWL showed an increase in the number of horizontal cells islet-1+, anda decrease in LIM 1+2. Conversely, LWL stimulated chicks showed Islet-1 diminished and LIM1+2increased. Besides, in the SWL group we observed a decrement in LIM1+2. Also changes wereobserved in the pattern of horizontal cells connections with cones.These results show that monochromatic stimulation change gene expression as well asmodify the connectivity of horizontal neurons. Postnatal visual experience showed plastic changesin the neuronal circuits in which subtype H1 and H3 of horizontal cells are involved. PIP00404