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Consolidation of hippocampus-dependent long-term memory requires the synthesis of plasticity-related proteins (PRPs). This protein synthesis (PS) is generally induced by a proper salient experience (strong event) that will be finally remembered. However, we have recently shown that a weak learning, normally resulting in a transient form of memory, can also result in a lasting protein synthesis-dependant memory trace by associatively interacting with a strong event, whereby the strong event "donors" PRPs to consolidate the memory of the weak event. This process was described as ´behavioral tagging´ (Moncada D and Viola H: Induction of Long-Term Memory by Exposure to Novelty Requires Protein Synthesis: Evidence for a Behavioral Tagging. J. Neurosci. 2007; 27(47): 12761-12763), resembling synaptic tagging originally described for long-term potentiation (LTP) and depression. We had further shown that the induction of a transient E-LTP can be reinforced into L-LTP by the associative interaction with specific strong behavioral events within effective time windows (Frey S and Frey JU: ´Synaptic tagging´ and ´cross-tagging´ and related associative reinforcement processes of functional plasticity as the cellular basis for memory formation. Prog. Brain. Res. 2008; 169: 117-143). The question now arises, if memory processes can be influenced by the association with LTP. Therefore, we trained rats in one of two different hippocampus-dependent tasks: inhibitory avoidance or spatial object recognition. Then, we investigated the outcome of LTP-induction on these processes. Here, we present first results, describing the effect of LTP-induction on qualitatively different memories induced by aversive and non-aversive training procedures in rats. References: 1 Moncada D and Viola H: J Neurosci. 2007 Nov 21;27(47):12761-3. 2 Frey S and Frey JU: Prog Brain Res. 2008;169:117-43. Review.