IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Neuroplastic changes in chick retina after spectral deprivation
Autor/es:
FOSSER, NICOLÁS S,; RONCO,LAURA; SÁNCHEZ, VIVIANA G.; BEJARANO, CLAUDIO ALEJANDRO,; RÍOS, HUGO
Lugar:
Florencia
Reunión:
Congreso; 8th IBRO WORLD CONGRESS OF NEUROCIENCE; 2011
Institución organizadora:
International Brain Research Organization
Resumen:
Neuroplastic changes in chick retina after spectral deprivation Nicolás S. Fosser, Laura Ronco, Viviana G. Sánchez, Claudio A. Bejarano and Hugo Ríos Instituto de Biología Celular y Neurociencias, Facultad de Medicina, UBA-CONICET Paraguay 2155, 3er p. Ciudad de Buenos Aires, ARGENTINA Color perception partially depends on the existence of different retinal photoreceptors expressing different opsins. Moreover, color vision depends on the integrity of the visual pathway and the early experience of individuals. On the other hand, color vision enhances our capability of environmental discrimination and it is an important aspect of intraspecific communication. We have use a tetrachromatic animal model, the Gallus domesticus, during the early postnatal developmental period in order to study how monochromatic stimulation modifies morphology and physiology of the retina. Monochromatic stimulation also implies an extent spectral deprivation. The present study analyzes the effect of monochromatic stimulation (long, middle and short wavelength) in a short-term exposure context. We focused in the outer retina, mainly in cone morphology through the analysis of some calcium binding proteins, and changes at the synaptic pedicle after spectral deprivation. We have found that double-cones show modifications in the size of their pedicle, and double and single cones increased their length between the oil droplet (outer limiting membrane) and the beginning of the outer plexiform layer. In addition, we found an increase in the amount of the synaptic vesicle protein SV2 in cone terminals at the outer plexiform layer, which might be interpreted as neuroplasticity . At the inner plexiform layer it can be described changes in the expression of calbindin D-28K, with a remarkable reduction on its relative quantity. In summary, we found a set of modifications in the chick deprived retina when animals were reared from hatching to 12 postnatal days in a monochromatic environment. These changes suggest neuroplastic adaptations to chromatic impoverish environment. Grant from CONICET PIP 00404.