New player in memory persistence: Retrosplenial Cortex

KATCHE, CYNTHIA; DORMAN, GUIDO; KRAMAR, CECILIA; GONZALEZ, CAROLINA; SLIPCZUK, LEANDRO; IZQUIERDO, IVAN; CAMMAROTA, MARTIN; MEDINA, JORGE H

Congreso; Society for Neuroscience 2011; 2011

Information storage in the brain is a temporally graded process involving several phases. Long-term memory (LTM), but not short-term memory (STM), requires de novo RNA synthesis around the time of training (1-3). Additionally, transcription of specific plasticity-related genes is dynamically regulated by neural activity during memory formation (4, 5). Although the hippocampus is crucial in the formation of new declarative memories, other brain regions probably mediate permanent storage of remote memories. Recently, several studies have revealed an involvement of the retrosplenial cortex (RSCx) in memory through brain activation and lesion studies in humans and rodents (6). For this reason, we decided to investigate the role of retrosplenial cortex and the molecular mechanisms involved in memory processing. In the present study we set to determine whether transcription and translation are involved in LTM formation and persistence, and whether c-Fos expression