IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Bringing synaptic tagging into behavior
Autor/es:
MARTÍNEZ, MARÍA CECILIA
Lugar:
Magdeburg
Reunión:
Simposio; Magdeburg International Neurobiological Symposium "Learning and Memory: Cellular and Systemic Views"; 2010
Institución organizadora:
Leibniz Institute for Neurobiology (IfN), SFB 779 Neurobiology of Motivated Behavior, Center for Behavioral Brain Sciences (CBBS)
Resumen:
In daily life, memories are intertwined events. Little is known
about the mechanisms involved in their interactions. Using two
hippocampus-dependent (spatial object recognition and contextual
fear conditioning) and one hippocampus-independent (conditioned
taste aversion) learning tasks, we show that in rats
subjected to weak training protocols that induce solely short term
memory (STM), long term memory (LTM) is promoted and formed
only if training sessions took place in contingence with a novel, but
not familiar, experience occurring during a critical time window
around training. This process requires newly synthesized proteins
induced by novelty and reveals a general mechanism of LTM
formation that begins with the setting of a learning tag established
by a weak training. These findings represent the first
comprehensive set of evidences indicating the existence of a
behavioral tagging process that in analogy to the synaptic tagging
and capture process, need the creation of a transient, protein
synthesis-independent, and input specific tag.