Behavioral tagging during an inhibitory avoidance task: identification of involved transmitter systems and learning tag-molecules in hippocampus-dependent long-term memory formation.

BALLARINI, FABRICIO; MONCADA, DIEGO; MARTINEZ, MARÍA CECILIA; ALEN, NADIA; VIOLA, HAYDÉE

Congreso; reunion conjunta de neurociencias (IIRCN); 2010

reunion conjunta de neurociencias (IIRCN)

Long-term memory consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have recently shown that the stabilization of the mnemonic trace also requires the setting of a learning tag able to capture those PRPs. Therefore memory consolidation can also be achieved capturing PRPs provided by another temporal-spatial closely-related event. Here, we studied the involvement of glutamatergic, dopaminergic and noradrenergic inputs on the setting of a learning tag and PRP-synthesis using an inhibitory avoidance (IA) training and the exploration of a novel open field (OF). Throughout pharmacological interventions around OF and/or IA sessions, we found that hippocampal dopamine D1/D5- and ©¬-adrenergic receptors are specifically required to induce PRP-synthesis. Moreover, the glutamatergic N-methyl-D-aspartate receptors were required for setting IA-learning tag, which machinery further required ¥áCAMKII and PKA but not ERK 1/2 activity. Our work emphasizes the essential role of the interaction between PRPs and learning tags for long-term memory formation.