Cannabinoids: A Group of Promising Neuroprotective Agents

BRUSCO, ALICIA; CALTANA LAURA

Neuroprotective Natural Products: Clinical Aspects and Mode of Action

Wiley-VCH

Lugar: Santiniketan; Año: 2016; p. 321 - 339

Cannabis constitutes the third most widely used drug after alcohol and tobacco;on the other hand, abundant evidences in experimental assays and clinical trialsshow that cannabis has a growing potential to treat different pathologies, including studies proposing cannabis to be the aspirin of the twenty‐first century [1].The endocannabinoid (eCB) system is a neuromodulatory system with importanthomeostatic roles controlling neuronal function, neurogenesis, inflammation,excitotoxicity, oxidative stress, and synaptic plasticity.In this context, this chapter summarizes eCB system biology and the potentialtherapeutic effects of natural cannabinoid compounds on the most representativeneuropathologies. To this end, the following sections focus on the cannabinoidsystem in the central nervous system.