Fetal heart rate variability responsiveness to maternal stress, non-invasively detected from maternal transabdominal ECG

MÜLLER, A.; LOBMAIER, SILVIA M.; SU, P. C.; BERG, G.; SHEN, C.; WU, H. T.; HALLER, B.; WEYRICH, J.; ZELGERT, C.; ANTONELLI, M. C.; SCHMIDT, G.; FABRE, B.; FRASCH, M. G.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS.

SPRINGER HEIDELBERG

Año: 2019 vol. 301 p. 405 - 414

0932-0067

Purpose Prenatal stress (PS) during pregnancy afects in utero- and postnatal child brain-development. Key systems afectedare the hypothalamic?pituitary?adrenal axis and the autonomic nervous system (ANS). Maternal- and fetal ANS activitycan be gauged non-invasively from transabdominal electrocardiogram (taECG). We propose a novel approach to assesscouplings between maternal (mHR) and fetal heart rate (fHR) as a new biomarker for PS based on bivariate phase-rectifedsignal averaging (BPRSA). We hypothesized that PS exerts lasting impact on fHR.Methods Prospective case?control study matched for maternal age, parity, and gestational age during the third trimesterusing the Cohen Perceived Stress Scale (PSS-10) questionnaire with PSS-10 over or equal 19 classifed as stress group (SG).Women with PSS-10