Cannabidiol-Enriched Extract Reduced the Cognitive Impairment but Not the Epileptic Seizures in a Lafora Disease Animal Model

ASO, ESTER; CALTANA, LAURA; FERRER, ISIDRE; GRAU-ESCOLANO, JORDI; SANZ, PASCUAL; ANDRÉS-BENITO, POL; BRUSCO, ALICIA

Cannabis and Cannabinoid Research

Mary Ann Liebert, Inc

Lugar: New York; Año: 2019 vol. 5 p. 1 - 14

2578-5125

Lafora disease (LD) is a rare form of progressive infantile epilepsy in which rapid neurological deterioration occurs as the disease advances, leading the patients to a vegetative state and then death, usually within the first decade of disease onset. Based on the capacity of the endogenous cannabinoid system (ECS) to modulate several cellular processes commonly altered in many neurodegenerative processes, as well as the antiepileptic properties of certain natural cannabinoids, the aim of this study was to evaluate the role of the ECS in LD progression.Materials and Methods: We tested whether a natural cannabis extract highly enriched in cannabidiol (CBD) might be effective in curbing the pathological phenotype of malin knockout (KO) mice as an animal model of LD.Results: Our results reveal for the first time that alterations in the ECS occur during the evolution of LD, mainly at the level of CB