Psychotic disorders in Argentine patients with refractory temporal lobe epilepsy: a case-control study

D ALESSIO LUCIANA; GIAGANTE BRENDA; PAPAYANNIS CRISTINA; ODDO SILVIA; SOLIS PATRICIA; DONNOLI VICENTE; KAUFFMAN MARCELO; CONSALVO DAMIAN; ZIEHER LUIS; KOCHEN SILVIA

EPILEPSY & BEHAVIOR (PRINT)

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2009 vol. 14 p. 604 - 609

1525-5050

The issue of psychotic disorders in epilepsy has given rise to great controversy among professionals; however, there are not many studies in this area and the physiopathological mechanisms remain unknown. The aim of this study was to describe the spectrum of psychotic disorders in an Argentine population with refractory temporal lobe epilepsy (RTLE) and to determine the risk factors associated with psychotic disorders. Clinical variables of the epileptic syndrome were compared among a selected population with RTLE with and without psychotic disorders (DSM-IV/Ictal Classification of psychoses). Logistic regression was performed. Sixty-three patients with psychotic disorders (Psychotic Group, PG) and 60 controls (Control Group, CG) were included. The most frequent psychotic disorders were brief psychotic episodes (35%) (DSM-IV) and interictal psychosis (50%) (Ictal Classification). Risk factors for psychotic disorders were bilateral hippocampal sclerosis, history of status epilepticus, and duration of epilepsy greater than 20 years.