IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Behavioral tagging is a general mechanism of long-term memory formation
Autor/es:
FABRICIO BALLARINI; DIEGO MONCADA; MARIA CECILIA MARTINEZ; NADIA ALEN; HAYDÉE VIOLA
Revista:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Editorial:
NATL ACAD SCIENCES
Referencias:
Año: 2009 vol. 16 p. 14599 - 14604
ISSN:
0027-8424
Resumen:
In daily life, memories are intertwined events. Little is known about
the mechanisms involved in their interactions. Using
two hippocampus-dependent (spatial object
recognition and contextual fear conditioning) and one
hippocampus-independent (conditioned
taste aversion) learning tasks, we show that in
rats subjected to weak training protocols that induce solely short term
memory
(STM), long term memory (LTM) is promoted and
formed only if training sessions took place in contingence with a novel,
but
not familiar, experience occurring during a
critical time window around training. This process requires newly
synthesized
proteins induced by novelty and reveals a general
mechanism of LTM formation that begins with the setting of a learning
tag
established by a weak training. These findings
represent the first comprehensive set of evidences indicating the
existence
of a behavioral tagging process that in analogy to
the synaptic tagging and capture process, need the creation of a
transient,
protein synthesis-independent, and input specific
tag.