IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Mechanisms that modulate and diversify BDNF functions: Implications for hippocampal synaptic plasticity
Autor/es:
RÍOS, ANTONELLA S.; DE VINCENTI, ANA PAULA; LEDDA, FERNANDA; PARATCHA, GUSTAVO; RÍOS, ANTONELLA S.; DE VINCENTI, ANA PAULA; LEDDA, FERNANDA; PARATCHA, GUSTAVO
Revista:
Frontiers in Cellular Neuroscience
Editorial:
Frontiers Media S.A.
Referencias:
Año: 2019 vol. 13
ISSN:
1662-5102
Resumen:
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established that BDNF function is controlled and diversified by molecular and cellular mechanisms including trafficking and subcellular compartmentalization of different Bdnf mRNA species, pre- vs. postsynaptic release of BDNF, control of BDNF signaling by tropomyosin receptor kinase B (TrkB) receptor interactors and conversion of pro-BDNF to mature BDNF and BDNF-propeptide. Defects in these regulatory mechanisms affect dendritic spine formation and morphology of pyramidal neurons as well as synaptic integration of newborn granule cells (GCs) into preexisting circuits of mature hippocampus, compromising the cognitive function. Here, we review recent findings describing novel dynamic mechanisms that diversify and locally control the function of BDNF in hippocampal neurons.