IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Comment to Tumour necrosis factor alpha gene -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis
Autor/es:
KAUFFMAN MARCELO; VILLA ANDRES MARIA
Revista:
JOURNAL OF NEUROIMMUNOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2009 vol. 212 p. 151 - 151
ISSN:
0165-5728
Resumen:
We have read the article by Losonczi et al. (2009) and have found it very interesting. They concluded thatTNFα–376Gallelemight be one of the factors responsible for progression in primary progressive multiple sclerosis (PPMS).We agree thatTNF gene variants might be considered a candidate to be involved in the genetics of MS. However, as the authors partiallymentioned, there have been different studies that have failed to find an association between these variants and MS susceptibility (Martinez et al., 2004). In fact, we have previously conducted a molecular epidemiological study in an Argentinean population with relapsing remitting MS and we did not find an association between TNF α –376 SNP and MS risk (Kauffman et al., 2007).