High Plasticity of New Granule Cells in the Aging Hippocampus

SULKES CUEVAS, JESSICA N.; MONZÓN-SALINAS, M. CRISTINA; SCHINDER, ALEJANDRO F.; BUTTNER, KARINA A.; FONTANET, PAULA A.; SULKES CUEVAS, JESSICA N.; MONZÓN-SALINAS, M. CRISTINA; PARATCHA, GUSTAVO; SCHINDER, ALEJANDRO F.; BUTTNER, KARINA A.; FONTANET, PAULA A.; PARATCHA, GUSTAVO; TRINCHERO, MARIELA F.; TEMPRANA, SILVIO G.; LEDDA, FERNANDA; TRINCHERO, MARIELA F.; TEMPRANA, SILVIO G.; LEDDA, FERNANDA

Cell Reports

Elsevier

Lugar: Amsterdam; Año: 2017 vol. 21 p. 1129 - 1139

2211-1247

During aging, the brain undergoes changes that impair cognitive capacity and circuit plasticity, including a marked decrease in production of adult-born hippocampal neurons. It is unclear whether development and integration of those new neurons are also affected by age. Here, we show that adult-born granule cells (GCs) in aging mice are scarce and exhibit slow development, but they display a remarkable potential for structural plasticity. Retrovirally labeled 3-week-old GCs in middle-aged mice were small, underdeveloped, and disconnected. Neuronal development and integration were accelerated by voluntary exercise or environmental enrichment. Similar effects were observed via knockdown of Lrig1, an endogenous negative modulator of neurotrophin receptors. Consistently, blocking neurotrophin signaling by Lrig1 overexpression abolished the positive effects of exercise. These results demonstrate an unparalleled degree of plasticity in the aging brain mediated by neurotrophins, whereby new GCs remain immature until becoming rapidly recruited to the network by activity. Trinchero et al. show that development of new granule cells born in the adult hippocampus is strongly influenced by age. In the aging hippocampus, new neurons remain immature for prolonged intervals, yet voluntary exercise triggers their rapid growth and functional synaptogenesis. This extensive structural remodeling is mediated by neurotrophins.