¡§PKMƒê INACTIVATION INDUCES SPATIAL FAMILIARITY

DIEGO MONCADA; HAYDEE VIOLA

LEARNING & MEMORY (COLD SPRING HARBOR, N.Y.)

Año: 2008 vol. 15 p. 810 - 814

1072-0502

Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMzeta levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMzeta, while inactivation of hippocampal PKMzeta by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMzeta is involved in setting a given context as a familiar place.