IBCN 20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Endogenous glucocorticoids participate in retinal degeneration during continuous illumination.
Autor/es:
EM. LÓPEZ, LK. JULIÁN, F. CAPANI, CB. CYMERYNG, H. COIRINI AND JJ. LÓPEZ-COSTA.
Revista:
THE INTERNATIONAL JOURNAL OF NEUROSCIENCE.
Editorial:
Taylor & Francis
Referencias:
Lugar: USA; Año: 2008 vol. 118 p. 1703 - 1725
ISSN:
0020-7454
Resumen:
Continuous illumination (CI) induces an oxidative stress of the retina which is involved in light induced retinal degeneration (LIRD).
As the increase of glucocorticoids could also collaborate in the damage, adrenalectomized (ADX) and sham operated rats (CTL) were submitted to CI, and their eyes were studied at light and electron microscopic levels.
After CI, ADX retinas were significantly thicker than CTL retinas. Retinal alterations appeared earlier and were more severe in CTL than in ADX retinas. Corticosterone levels increased gradually in the sera of CTL rats along CI. These results suggest that adrenalectomy attenuates LIRD supporting the hypthesis.
