IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Amnesia of inhibitory avoidance by scopolamine is overcome by previous open-field exposure
Autor/es:
N COLETTIS; M SNITCOFSKY; E KORNISIUK; E N GONZALEZ; J QUILLFELDT; D JERUSALINSKY
Revista:
LEARNING & MEMORY (COLD SPRING HARBOR, N.Y.)
Editorial:
COLD SPRING HARBOR LAB PRESS
Referencias:
Año: 2014 vol. 21 p. 634 - 645
ISSN:
1072-0502
Resumen:
The muscarinic cholinergic receptor (MAChR) blockade with scopolamine
either extended or restricted to the hippocampus, before or after
training in inhibitory avoidance (IA) caused anterograde or retrograde
amnesia, respectively, in the rat, because there was no long-term memory
(LTM) expression. Adult Wistar rats previously exposed to one or two
open-field (OF) sessions of 3 min each (habituated), behaved as control
animals after a weak though over-threshold training in IA. However,
after OF exposure, IA LTM was formed and expressed in spite of an
extensive or restricted to the hippocampus MAChR blockade. It was
reported that during and after OF exposure and reexposure there was an
increase in both hippocampal and cortical ACh release that would
contribute to "prime the substrate," e.g., by lowering the synaptic
threshold for plasticity, leading to LTM consolidation. In the frame of
the "synaptic tagging and capture" hypothesis, plasticity-related
proteins synthesized during/after the previous OF could facilitate
synaptic plasticity for IA in the same structure. However, IA
anterograde amnesia by hippocampal protein synthesis inhibition with
anisomycin was also prevented by two OF exposures, strongly suggesting
that there would be alternative interpretations for the role of protein
synthesis in memory formation and that another structure could also be
involved in this "OF effect."