IBCN 20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
On the role of retrosplenial cortex in long-lasting memory storage
Autor/es:
KATCHE, CYNTHIA; DORMAN, GUIDO; GONZALEZ, CAROLINA; KRAMAR, CECILIA P; SLIPCZUK, LEANDRO; ROSSATO, JANINE; CAMMAROTA, MARTIN; MEDINA, JORGE H
Revista:
HIPPOCAMPUS
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2013 p. 295 - 302
ISSN:
1050-9631
Resumen:
The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.
