IBCN 20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Nicotine modulates the long-lasting storage of fear memory
Autor/es:
RAMON H LIMA; ANDRESSA RADISKE; CRISTIANO A KOHLER; CAROLINA GONZALEZ; LIA R BEVILAQUA; JANINE ROSSATO; JORGE H. MEDINA; MARTIN CAMMAROTA
Revista:
LEARNING & MEMORY (COLD SPRING HARBOR, N.Y.)
Editorial:
COLD SPRING HARBOR LAB PRESS
Referencias:
Año: 2013 p. 120 - 124
ISSN:
1072-0502
Resumen:
Late post-training activation of the ventral tegmental area (VTA)-hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA-hippocampus dopamine connections.
