IBCN 20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Notch destabilises maternal B-catenin and restricts dorsal-anterior development in Xenopus
Autor/es:
HELENA ACOSTA ; SILVIA L. LÓPEZ ; DIEGO R. REVINSKI ; ANDRÉS E. CARRASCO
Revista:
DEVELOPMENT
Editorial:
COMPANY OF BIOLOGISTS LTD
Referencias:
Año: 2011 vol. 138 p. 2567 - 2579
ISSN:
0950-1991
Resumen:
The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangolds organiser and also contains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of -catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises b-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain.
