IBCN   20355
INSTITUTO DE BIOLOGIA CELULAR Y NEUROCIENCIA "PROFESOR EDUARDO DE ROBERTIS"
Unidad Ejecutora - UE
artículos
Título:
Hypothermia prevents the development of ischemic proliferative retinopathy induced by severe perinatal asphyxia
Autor/es:
REY FUNES M.; IBARRA M.; DORFMAN V.; LOPEZ E.M.; LOPEZ COSTA J.J..; COIRINI H.; LOIDL C.F.
Revista:
EXPERIMENTAL EYE RESEARCH
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Año: 2010 p. 113 - 120
ISSN:
0014-4835
Resumen:
Hypothermia prevents the development of ischemic proliferative retinopathy induced by severe perinatal asphyxia
Manuel Rey-Funes a, Mariano Esteban Ibarra a, Veronica Berta Dorfman a, Ester Maria Lopez a, Juan Jose´ Lopez-Costa a, Hector Coirini b,c, Cesar Fabian Loidl a,*
a b s t r a c t
Obstetric complications, such as perinatal asphyxia, may cause retinal injuries as retinopathy of
prematurity (ROP), a type of ischemic proliferative retinopathy. Up to date there are no appropriate
experimental models for studying the long-term sequels of this disease. In the present work, we present
an experimental model of perinatal asphyxia which shows structural and ultrastructural retinal alterations
at the most inner layers of the retina, such as neurodegeneration, development of neoformed
vessels and glial reaction, which are compatible with the histopathological description of ROP. Besides,
the application of hypothermia during perinatal asphyxia showed effective results preventing cellular
and morphological alterations. This study may contribute to the development of therapies in order to
either ameliorate or prevent retinal damage. In this manner, hypothermia may improve life quality and
decrease medical, family and social costs of these avoidable causes of blindness.