Administration of caseinomacropeptide-enriched extract to mice enhances the calcium content of femur in a low-calcium diet

BURNS, P.; BINETTI, A.; TORTI, P.; KULOSIK, U.; FORZANI, L.; RENZULLI, P.; VINDEROLA, G.; REINHEIMER, J.

INTERNATIONAL DAIRY JOURNAL

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2015 vol. 44 p. 15 - 20

0958-6946

Caseinomacropeptide is the 64 C-terminal amino acids residue of κ-casein, formed by chymosin cleavage during cheese manufacture. The aim of this study was to examine the effects of the oral administration of a CMP-enriched extract (CMPEE) obtained at a local dairy plant on the Ca content of femur in mice. Animals received low (0.1% w/v), normal (0.5% w/v) or high (1.2% w/v) Ca diet for 3 or 8 weeks and CMP diluted (1:10) in their drinking water. No significant differences in Ca content were observed in feces, kidney, urine or blood serum compared to control animals. The oral administration of CMP to mice significantly enhanced the Ca content in femur under a low-Ca diet model, especially during the period of full body development (3 weeks), where a significant 12% of Ca increase was observed. These findings pave the way for further studies aimed at supplementing infant food with industrially-obtained CMP-enriched extract for enhanced bone health.