Characterization of the Enalapril:b-cyclodextrin complex in solid state

A. ZOPPI; C. GARNERO; YAMILA GARRO LINCK; ANA K. CHATTAH; GUSTAVO A. MONTI; M. R. LONGHI

Estancia San Pedro, Brasil

Simposio; II Latin- American Symposium on Polymorphism and Crystallization in Drugs and Medicines LAPOLC 09; 2009

<!-- /* Font Definitions */ @font-face {font-family:Helvetica; panose-1:2 11 6 4 2 2 2 3 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:7 0 0 0 147 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; mso-layout-grid-align:none; punctuation-wrap:simple; text-autospace:none; font-size:10.0pt; font-family:Helvetica; mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:Helvetica; mso-ansi-language:EN-US; mso-fareast-language:EN-US;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> The main objective of this work was to study an inclusion complex between enalapril (ENA), and β-cyclodextrin (β-CD) in solid state. Inclusion complexes were prepared by liophilization method in the 1:1 molar ratio. The physical mixtures (PM) were also prepared in the same ratio. The full characterization of the complex was performed by powder x-ray diffraction, scanning electron microscopy and solid state nuclear magnetic resonance. These techniques confirmed the formation of an inclusion complex between ENA and β-CD in the solid state, as well as showed the amorphous nature of the solid obtained. When studying the chemical stability of ENA complexed to β-CD, a clear stabilizing effect was observed.