Characterization of the Enalapril:beta-cyclodextrin complex in solid state

A. ZOPPI; C. GARNERO; Y. GARRO LINCK; A. K. CHATTAH; G. A. MONTI; M. R. LONGHI

Estancia San Pedro, Brasil

Congreso; LAPOLC 09; 2009

Enalapril (ENA) suffers degradation in the solid state as a consequence of its interaction with excipients, a fact that causes an important stability problem when considering its formulation1.  A strategy used to increase the stability of drugs is the formation of complexes with macromolecules, of which molecular encapsulation with â-cyclodextrin (â-CD) constitutes an alternative for the development of new pharmaceutical dosage forms2. Previously, we have reported the preparation and partial characterization of the ENA:â-CD complex3. In this work we have employed powder x-ray diffraction, scanning electron microscopy (SEM) and solid state nuclear magnetic resonance in order to complete the characterization of the complex in solid state. Also we evaluated the chemical stability of the complex in the presence of excipients.