IFEG   20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
NEVIRAPINE CO-CRYSTALS ? STRUCTURE DETERMINATION USING X-RAY DIFFRACTION AND SOLID STATE NMR SPECTROSCOPY
Autor/es:
YAMILA GARRO LINCK; ROGERIA N. COSTAS; HELVECIO V. H. ROCHA; JACKSON A. L. C. RESENDE; GUSTAVO A. MONTI; SILVIA L. CUFFINI
Reunión:
Otro; 5th International School of Crystallization: Drugs, Foods, Agrochemicals, Minerals, New Materials ISC2016; 2016
Resumen:
The antiretroviral drug Nevirapine (NVP) (figure 1a) is a non-nucleoside reversetranscriptase inhibitor, used in the treatment of HIV-1 infection. According to the Biopharmaceutics Classification System (BSC)1, it is a class II drug, exhibiting low solubility and high permeability. To increase the drug dissolution and its bioavailability, different preparation methods with crystal modification such as co-crystals were studied. NVP molecule has a Conformationally rigid amide group that allows a cocrystal formation with soluble carboxylic acids or amide co-formers2. Caira et al. reported the crystal structure and solid state properties of several NVP co-crystals2.We prepared different co-crystals of NVP and they were identified using their crystal structure Caira published data. The only case where we observed differences was for NVP-salicylic acid (NVP-AS). Our data presented different reflections in comparison with reported data. Therefore, the goal of this work was to determinate the crystal structure of NVP-AS using single crystal X-ray diffraction in combination with solid state NMR spectroscopy in order to confirm our crystal structure results.