IFEG   20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
STRUCTURE OF NEVIRAPINA CO-CRYSTAL USING SINGLE CRYSTAL X-RAY DIFFRACTION AND SOLID STATE NMR SPECTROCOPY
Autor/es:
YAMILA GARRO LINCK; HELVECIO V. H. ROCHA; ROGERIA N. COSTAS; JACKSON A. L. C. RESENDE; GUSTAVO A. MONTI; SILVIA L. CUFFINI
Lugar:
Rio de Janeiro
Reunión:
Seminario; XV Latin American Seminary of Analysis by X-Ray Techniques ? SARX 2016; 2016
Resumen:
The antiretroviral drug Nevirapine (NVP) (11-Cyclo-propyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2?,3?-e][1,4]diazepin-6-one) is a non-nucleoside reverse transcriptase inhibitor, used in the treatment of HIV-1 infection. It is a class II drug according the Biopharmaceutics Classification System (BSC)1, exhibiting low solubility and high permeability. To increase the drug dissolution and its bioavailability, the different preparation methods with crystal modification such as co-crystals were studied. Co-crystals are multicomponent crystalline solids which have different drug molecules or a drug and a non-volatile substance in its structure. NVP molecule has a conformationally rigid amide group that allows a co-crystal formation with soluble carboxylic acids or amide co-formers2. Caira et. al. reported the crystal structure and solid state properties of several NVP co-crystals2. We prepared different co-crystals of NVP and they were identified the crystal structure using Caira published data. The only the case that we observed differences was for NVP salicylic acid (NVP-AS). Our data presented different reflections in comparison with reported data. Therefore, the goal of the work was to determinate of NVP-AS using single crystal X-ray diffraction in combination with solid state NMR spectroscopy in order to validate our crystal structure results.