Could T. Rangeli protect us from Chagas disease?.

S. P, VEGA; G. J. SIBONA

Carlos Paz

Workshop; XIII Latin American Workshop on non-linear Phenomena: LAWNP?13; 2013

FaMAF-UNC

It has been shown in murine models that an infection with the parasite Trypanosoma rangeli decreases the parasite levels of a Trypanosoma cruzi (causing agent of the Chagas disease) later infection. In this work we present a mathematical model that describe this situation, taking into account the no intracellular replication of the T. rangeli, the delay in the answer of the mammal immunological system against the T. cruzi infection and its intracellular reproductive cycle as well. In general we show that a parasite mixed infection exhibits one of three possible stationary states: Healing, Chronic Parasitemia and Dead. The model reproduces experimental data from murine models found in the literature. As a nal remark we demonstrate that the protective eect against Chagas disease obtained by preinfecting with T. rangeli is just temporary.