IFEG   20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A way to Protect Against Chagas Disease
Autor/es:
VEGA SHIRLENE, SIBONA GUSTAVO
Lugar:
Cabo Frio
Reunión:
Workshop; Workshop on Mathematical Methods and Modeling of Biohysical Phenomena; 2013
Institución organizadora:
Universidad de Sao Paulo
Resumen:
Tittle: Mixed Infections: A Way to Protect Against Chagas Disease Abstract: It has been shown in murine models that an infection with the parasite Trypanosoma rangeli decreases the parasite levels of a Trypanosoma cruzi (causing agent of the Chagas disease) later infection. In this work we present a mathematical model that describe this situation, taking into account the no intracellular replication of the T. rangeli, the delay in the answer of the mammal immunological system against the T. cruzi infection and its intracellular reproductive cycle as well. In general we show that a parasite mixed infection exhibits one of three possible stationary states: Healing, Chronic Parasitemia and Dead. The model reproduces experimental data from murine models found in the literature. As a final remark we demonstrates that the protective effect against Chagas disease obtained by preinfecting with T. rangeli is just temporary.