Intercalation of anti-inflammatory drugs Sodium Indomethacin into nanocomposites of Mg-Al. Structural characterization

MENDIETA S; REYES NUÑEZ, P; OLIVA, M.I.; PEREZ, C.; FERNANDEZ, J.; CRIVELLO, M. E.

Rosario

Congreso; SAM 2011; 2011

Sociedad Argentina de Metalurgia Filial Rosario

Layered double hydroxides (LDH) have many applications as matrices in pharmaceutical fields. -Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) and the salt Sodium Indomethacin (INDONa) have been used as host drugs to be intercalated into LDH. As consequence of salt formation a polymorph of indomethacin was obtained. Intercalated compound was prepared via ion exchange and co-precipitation. As consequence of the intercalation, the interlayer distance of the host increased. The NSAID and LDH-INDONa were characterized by XRD, FT-IR and drug content was determinate by UV spectroscopy. The highest percentage of INDONa load was observed in the LDH-CI incorporated by direct method (48.40 wt%).