Fe(III) saleen derived schiff base complexes as potential contrast agents

CARDOSO, B.; VICENTE, A.; WARD, J. B.; PEDRO J. SEBASTIÃO; FABIAN VACA CHAVEZ; S. BARROSO; A. CARVALHO; KEELY, S.; MARTINHO, P.; CALHORDA, M. J.

INORGANICA CHIMICA ACTA

ELSEVIER SCIENCE SA

Lugar: Amsterdam; Año: 2015

0020-1693

Three iron(III) complexes with ligands derived from N-ethyl-N-(2-aminoethyl)salicylaldiminate (H, 1; 5-Br, 2; 3-OMe, 3 substituents at the phenyl group) were prepared and the X-ray crystal structures of 1 and2 are reported. NMR studies of solutions of these complexes in DMSO allowed for investigation of theirmagnetic behaviour and paramagnetic relaxation contribution. The relaxivities measured ranged from0.35 to 0.80 mM1 s1 for proton Larmor frequencies from 0.01 to 300 MHz, in agreement with thoseknown for other iron(III) based contrast agents. Biological studies on colonic epithelial T84 cell monolayersshowed that the compounds exert toxic effects only at concentrations higher than 100 lM whilecoincidently reducing colonic epithelial secretory function. These two features make these complexesgood candidates for further development in order to be used as MRI contrast agents.