IFEG   20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
artículos
Título:
Improving furosemide polymorphs properties through supramolecular complexes of beta-cyclodextrin
Autor/es:
CLAUDIA GARNERO; ANA K. CHATTAH; MARCELA R. LONGHI
Revista:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 95 p. 139 - 145
ISSN:
0731-7085
Resumen:
In this work, complexes of B-cyclodextrin and the two solid forms of furosemide were prepared and characterized for their potential pharmaceutical applications, with the interactions between the two compounds being studied in the solution and solid states. The solubility studies revealed different behaviors of the polymorphs. In particular, it was observed that the binary complex significantly increased the solubility of furosemide form I in the gastric simulated fluid, which resulted in a rise in the bioavailability of this formulation after oral administration. In addition, results using ssNMR, FT-IR, DSC, TGA, SEMand XRPD provided evidence of the formation of complexes after utilizing kneading and freeze-drying methods. A comparison with previous developed complexes that used maltodextrin as the ligand wasperformed. Our results suggest that these novel supramolecular complexes showed promise to be usedin drug delivery systems with an application in pharmaceutical formulations.