IFEG   20353
INSTITUTO DE FISICA ENRIQUE GAVIOLA
Unidad Ejecutora - UE
artículos
Título:
Intercalation of anti-inflammatory drugs Sodium Indomethacin into nanocomposites of Mg-Al. Structural characterization.
Autor/es:
MENDIETA, S.; REYES NUÑEZ, P.; OLIVA, M.I.; FERNANDEZ, J.; CRIVELLO, M.E.
Revista:
Procedia Materials Science
Editorial:
ELSEVIER SCIENCE
Referencias:
Año: 2012 p. 580 - 587
ISSN:
2211-8128
Resumen:
Layered double hydroxides (LDH) have many applications as matrices in pharmaceutical fields. -Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) and the salt Sodium Indomethacin (INDONa) have been used as host drugs to be intercalated into LDH. As consequence of salt formation a polymorph of indomethacin was obtained. Intercalated compound was prepared via ion exchange and co-precipitation. As consequence of the intercalation, the interlayer distance of the host increased. The NSAID and LDH-INDONa were characterized by XRD, FT-IR and drug content was determinate by UV spectroscopy. The highest percentage of INDONa load was observed in the LDH-CI incorporated by direct method (48.40 wt%).