BEHAVIORAL AND MOLECULAR CHANGES INDUCED BY EARLY NOISE EXPOSURE USING DIFFERENT EXPOSURE SCHEDULES. PARTIAL REVERSAL AFTER REARING IN AN ENRICHED ENVIRONMENT.

MOLINA, SJ, MICELI, M, CAPANI, F AND GUELMAN LR.

Congreso; Meeting Falan; 2016

Falan

BEHAVIORAL AND MOLECULAR CHANGES INDUCED BY EARLY NOISE EXPOSURE USING DIFFERENT EXPOSURE SCHEDULES. PARTIAL REVERSAL AFTER REARING IN AN ENRICHED ENVIRONMENT.Molina, SJ1, Miceli, M1, Capani, F2 and Guelman LR1.1Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Estudios Farmacológicos y Botánicos (CEFYBO-UBA-CONICET). Facultad de Medicina. 1ª Cátedra de Farmacología. Buenos Aires, Argentina.2Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Cardiológicas Prof. Dr. Alberto Taquini (ININCA-UBA-CONICET). Facultad de Medicina. Buenos Aires, Argentina.Different schedules of noise exposure can induce different behavioral hippocampal-related changes in immature rats. Moreover, rearing animals in an enriched environment (EE) has shown to be effective in the reversal of most alterations. However, comparative data of hippocampal oxidative levels were not obtained yet. Thus, the aim of this work was to test potential schedule-related differences in hippocampal oxidative status as well as related behavioral parameters. The possible reversal of these changes by rearing in an EE was also assessed.Male Wistar rats of 7 days were exposed to noise (95-97 dB, 2h daily, for one or five days). After weaning, rats were transferred to an EE or to standard cages. After one week, behavioral tests and levels of Trx1, an antioxidant of the thioredoxin family, were tested. Results showed that noise exposure might induce dissimilar hippocampal-related behavioral and Trx1 changes, depending on the schedule of exposure. Moreover, rearing in an EE was effective in modifying some of these endpoints. However, although 5-days exposed rats appeared to be more vulnerable to noise-induced changes than 1-day exposed animals, EE was equally effective in reversing changes in both groups.Therefore, it could be concluded that although the repeated exposure to noise might be more damaging on behavioral and oxidative measures, visual, social and physical stimulation during the development seemed to be an effective strategy to reverse all noise-induced changes.