INVESTIGADORES
CAPANI Francisco
congresos y reuniones científicas
Título:
Neuroprotective role of Oleoylethanolamide in a rat model of perinatal asphyxia
Autor/es:
MARÍA INÉS HERRERA , JUAN IGNACIO ROMERO, PABLO GALEANO , MARIANA HOLUBIEC , TAMARA LOGICA TORNATORE , PABLO VASQUEZ, FERNANDO RODRÍGUEZ DE FONSECA, EDUARDO BLANCO CALVO, FRANCISCO CAPANI
Reunión:
Congreso; Congreso de la Sociedad Argentina de Neurociencias; 2015
Resumen:
IntroductionPerinatal asphyxia (PA) is still associated with neurological morbidity and implies overactivation of inflammatory response. The absence of an established treatment for PA encourages research on neuroprotective mechanisms. N- acylethanolamides have exerted anti-inflammatory actions via PPARα activation in several models of brain injury. However, its role in perinatal hypoxic brain injury remains still unknown. The aim of our study is to evaluate the neuroprotective role of Oleoylethanolamide (OEA) treatment in 30 days-old asphyctic rats. Methods A rat model of global severe PA was performed [1, 2, 3]. The sample (N=24) consisted of male Sprague Dawley rat pups and was divided into 4 groups: asphyctic rats undergoing to vehicle treatment (PA20), asphyctic rats subjected to treatment with OEA (PA20 OEA10), control of cesarean delivery undergoing to vehicle treatment (C+), control of cesarean delivery subjected to treatment with OEA (C+ OEA10). The respective treatment was performed within the first hour of life by subcutaneous injection. Rats were subjected to behavioral tests. Results Asphyctic rats treated with OEA (10 mg/kg) showed an improvement in exploratory locomotion in Elevated Plus Maze test. Conclusions OEA may exert a neuroprotective effect in perinatal asphyxia. Further studies are being carried out in our laboratory to determine if OEA might have some protective effects on synaptic structure and functions. 1Bjelke B, Anderson K, Ogren SO, Bolme P. Brain Res. 1991; 543: 1-9.2Capani F et al. Exp Neurol. 2009; 219: 404-413.3Saraceno GE, Bertolino ML, Galeano P, Romero JI, García Segura LM, Capani F. Exp Neurol. 2010; 223, 615-622.