Effects of perinatal asphyxia on the expression of the acylethanolamide/endocannabinoid signaling system in the hippocampus and dorsal striatum

PABLO GALEANO, EDUARDO BLANCO, MARIANA I. HOLUBIEC, JUAN I. ROMERO, TAMARA M. A. LOGICA TORNATORE, JUAN SUAREZ, FRANCISCO J. PAVÓN, FRANCISCO CAPANI, FERNANDO RODRÍGUEZ

Congreso; I Congreso Internacional de Psicobiología; 2015

Perinatal asphyxia (PA) is an obstetric complication caused by oxygen deprivation (hypoxia) or a reduced blood flow (ischemia) to different body organs, including the central nervous system (CNS). Within the CNS, the hippocampus and the striatum are particularly vulnerable areas to PA. Nowadays, PA is considered as one of the principal causes of morbimortality in term and pre-term neonates, and is associated with an increased likelihood of suffering from cerebral palsy, mental retardation, learning disabilities, ADHD, among others. The endocannabinoid system (ECS) is a lipid transmitter system involved in a variety of physiological processes including appetite, pain, synaptic plasticity, memory and mood regulation. Endocannabinoids, and other acylethanolamides (AEs) without endocannabinoid activity, have recently received growing attention as they have potential neuropro