INVESTIGADORES
CAPANI Francisco
congresos y reuniones científicas
Título:
Is estradiol treatment a proper strategy for neurodevelopmental disorders associated with perinatal asphyxia?
Autor/es:
SARACENO, GE.1; BELLINI, MJ.2; GALEANO, P.1; ROMERO, JI.1; HOLUBIEC, M.1; LOGICA, T.1; KOLLIKER, RA.1; GARCíA-SEGURA, LM.2; CASTILLA, R.1; CAPANI, F.
Reunión:
Congreso; Congreso de la Sociedad Argentina de Neurociencias; 2012
Resumen:
Even though neurodevelopmental disorders (NDDs) are known to begin before birth, some of them manifest afterwards. Perinatal asphyxia (PA) is an important risk factor for several NDDs since it affects the accurate establishment of neural circuits during a period of apparent normal development. We address the evolution of the damage in CA1 hippocampal area induced by PA in rats using different cytoskeleton markers associated with NDDs. At 30 days of age we observed increased spinogenesis, augmented number of mushroom-type dendritic spines (MDS) and higher â-actin mRNA and protein levels. At 120 days of age we found reactive gliosis, dendritic morphological alterations, increased phosphorylation status of neurofilaments, decreased MDS and increased thickness of postsynaptic densities. Regarding these results, we employed an estradiol treatment (250ug/kg, 3 days) whereby the long term alterations induced by PA were reversed through the activation of the ERá/IGF-IR signaling pathway. These results support our working hypothesis that PA induces age-dependent alterations in synaptic connectivity before the establishment of symptoms associated with NDDs. Moreover, ERá/IGF-IR signaling pathway may represent a therapeutic target for the treatment of PA-induced neurological alterations.