INVESTIGADORES
CAPANI Francisco
capítulos de libros
Título:
Immune System Links Psoriasis-Mediated Inflammation to Cardiovascular Diseases via Traditional and Non-Traditional Cardiovascular Risk Factors
Autor/es:
KÖLLIKER-FRERS, MATILDE OTERO-LOSADA, EDUARDO KERSBERG, VANESA COSENTINO AND FRANCISCO CAPANI
Libro:
Medicine » "An Interdisciplinary Approach to Psoriasis
Editorial:
Intech
Referencias:
Año: 2017; p. 2 - 31
Resumen:
Background. Cutaneous psoriasis and psoriatic arthritis increase the risk of cardiovasculardiseases though the reasons are not clear. Here we discuss the role of the immunesystem in atherosclerosis and of the proinflammatory status in psoriasis and psoriaticarthritis diseases.Methods. We performed a Pubmed query covering publications within the last ten yearsincluding epidemiological studies, cross-sectional case-control studies, and reviews.Articles were selected according critical associations using arthritis, immune-mediatedinflammatory diseases, and psoriasis as key fields. These were crossed and combined withatherogenesis, endothelial dysfunction, intima-media thickness, subclinical atherosclerosis,plaque, thrombosis, thrombus, fibrinolysis, coagulation, and reactive oxygen species,all closely related to cardiovascular diseases. Both types of disease selected terms were separatelycombined with cardiovascular risk factors both non-traditional (innate and adaptivepro- and anti-inflammatory immune molecules and cells), and traditional (metabolicconditions and related molecules).Results and conclusions. Immune-activated crossroads came out as the main contributorsto proatherogenic inflammation in psoriasis and psoriatic arthritis disease.Traditional and non-traditional cardiovascular risk factors´ interactions result froman active cross-talk between proatherogenic mediators derived from metabolic, vascularand autoimmune joint and skin inflammation in target tissues. Consistently,psoriasis and psoriatic arthritis diseases offer an invaluable scenario to deepen ourknowledge on atherosclerotic cardiovascular disease.