INVESTIGADORES
CHEHIN Rosana Nieves
congresos y reuniones científicas
Título:
Protective effect of thyroxine, 3,5,3´-triiodothyroacetic acid and 3,5,3´,5´tetraiodothyroacetic acid on serum albumin fibrilation
Autor/es:
CORTEZ, LM; FARÍAS R.N; CHEHÍN R.
Lugar:
La Plata- Argentina
Reunión:
Congreso; . XXXVII Reunión Anual de la Sociedad Argentina de Biofísica.; 2008
Institución organizadora:
SAB
Resumen:
Inhibition or reversion of protein self-aggregation has been suggested as a possible preventive mechanism against amyloid diseases and many efforts are underway to found out molecules capable to restrain the protein aggregation process. In the present work, the inhibitory effects of thyroid hormone analogues on heat-induced fibrillation process of serum albumin are reported. Among the analogues tested, 3,5,3’,5’-tetraiodothyroacetic and 3,5,3’-triiodothyroacetic acid showed the most important inhibitory effects on amyloid formation. Thyroxine exhibit a lesser protective effect while 3,5,3’-triiodothyronine showed no significant inhibition. The gaining of a negative charge together with a size reduction of the hormone molecule could play an essential role in the inhibition of fibrils formation. According to FTIR spectroscopy results, the thyroid hormones analogues protective effects proceed via the stabilization of the protein native structure. The current work demonstrates the effectiveness of natural occurring molecules in the inhibition of albumin fibrils formation and also suggests a new non-genomic function of the thyroid hormones.