Protective effect of 3,5,3’-triiodothyroacetic and 3,5,3’,5’-tetraiodothyroacetic acids on serum albumin fibrillation

CORTEZ, LM; FARÍAS, R.N.; CHEHÍN, R.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Springer

Lugar: Heidelber, Germany; Año: 2009 vol. 38 p. 857 - 863

0175-7571

Inhibition or reversion of protein self-aggregation has been suggested as a possible preventive mechanism against amyloid diseases, and many efforts are underway to found out molecules capable to restrain the protein aggregation process. In this paper, the inhibitory effects of thyroid hormone analogues on heat-induced fibrillation process of serum albumin are reported. Amongthe analogues tested, 3,5,30,50-tetraiodothyroacetic and 3,5,30-triiodothyroacetic acid showed the most important inhibitory effects on amyloid formation. Thyroxine exhibits a lesser protective effect, while 3,5,30-triiodothyronine showed no significant inhibition. The gaining of a negative charge together with a size reduction of the hormone molecule could play an essential role in theinhibition of fibrils formation. According to infrared spectroscopy results, the thyroid hormones analogues protective effects proceed via the stabilization of the protein native structure. The current work demonstrates the effectiveness of naturally occurring molecules in the inhibitionof albumin fibril formation.