Analysis of the genetic Substructure in Argentina using fifteen microsatellites loci.

MARINO M; BOBILLO C; A, SALA; CORACH D

Copenhague (Dinamarca).

Congreso; XII Jornadas del GEP-ISFG; 2007

Grupo Esañol y Portugues-ISFG

It has been shown by Y-SNPs and mtDNA-hg that the population of Argentina is genetically heterogeneous, with relevant Native American and European contributions to its extant population. In order to test if genetic substructure can be detected by autosomal markers, a set of 15 STRs (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX y FGA) were analyzed in 5,282 individuals inhabiting 10 provinces: Buenos Aires, Santa Fe, Mendoza, Río Negro, Chubut, Misiones, Formosa, Chaco, Corrientes and Salta. Allele frequencies, Hardy-Weinberg equilibrium and genetic distance, determined by Fst, were establish between the sampled populations. The results obtained indicate that the genetic distance are non significant between most of the sampled populations, being Salta the only one that significantly differs respect to most of the compared provinces (Fst: 0.00484-0.01601, p: 0.0498-0.0000). In order to broaden the comparison, previously published information of five additional provinces (N=1,994), were included in the analysis. The extended results showed that genetic distance are non significant between these fifteen provinces, with the exception of Salta sample. These results might suggest that genetic sub-structure can?t be detected by the autosomal STRs in the 15 populations considered. Accordingly, a database of the whole country is needed, for the correct interpretation of the result in paternity testing and forensic casework.