On-Line Autosomal and Y-STRs Genetic Marker Reference Data Base of Argentina.

MIGUEL MARINO, ANDREA SALA AND DANIEL CORACH

Ponta Delgada, Azores

Congreso; 21 st Congress International Society for Forensic Genetics; 2005

International Society for Forensic Genetics

Autosomal and Y chromosome-specific short tandem repeats (STRs) became the genetic markers of choice for individual identification. In addition, these markers also became powerful tools to assist  molecular anthropologists. The availability of internet on-line reference databases may contribute  either with forensic scientists or molecular anthropologists to obtain genetic information that may be continuously updated. At the Servicio de Huellas Digitales Genéticas  (Genetic Fingerprinting Service, University of Buenos Aires) we constructed an interactive reference database that includes a set of fifteen autosomal STRs (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX and FGA) as well as a set of Y-STRs (DYS19, DYS389I/II, DYS390, DYS391, DYS392, DYS393 and DYS385a/b). The complete set of data corresponding to 2003 includes  2710 samples typed with autosomal markers and  239 samples typed with the minimal haplotype (nonaplex)  Y-STRs. The search can be done by choosing all the country or  by choosing a particular province. In the database are included 10 provinces: Buenos Aires, Santa Fe, Rio Negro, Chubut, Mendoza, Misiones, Corrientes, Formosa, Chaco and Salta. To evaluate allele or haplotype frequencies in a given province the cursor selects the province from the map of Argentina, the genetic marker is selected by clicking on the ideogram of a metaphase graph in which the markers are located. During July the previous year information is being updated. The frequencies can be determined for a particular year or as a combined information. In addition since it is a modular program the number and type of markers can be increased or included. It also includes mutation frequency of the markers described.  This contribution offers a rapid tool for assessing genetic information on-line in order to improve data access.