Analysis of high mutable Y-STRs in urban and amerindian Argentinean population

BOBILLO C; SALA A; CORACH D

Kracovia

Congreso; 26th ISFG Congress International Society for Forensic Genetics; 2015

International Society of Forensic Genetic

The Y-chromosome STR analysis has been useful inestablishing patterns of human migrations through the characterization ofpaternal lineages and has also been used for forensic and anthropologicalpurposes. However these markers exhibit a limitation concerning its mutationrates. On one hand, recurrent mutations lead to observe individuals withidentical haplotypes without belonging to the same patrilineage, and on theother, low mutation rates make difficult to differentiate between haplotypesthat share the same Y-chromosome linage.Recently, a battery of Y-STRs with a very highmutation rate has been developed, called ?rapidly mutating (RM) Y-STRs?, theirmain feature allows focusing their use under a newperspective in forensics. In order to evaluate their forensic parameters weanalyzed two population groups from Argentina: an urban (N=297) population anda set of samples (N=175) belonging to different Native American groups.The results showed that the average genediversity (GD) was higher in urban populations (0,8471) compared with theisolated groups (0,8322). Moreover, haplotype sharing within populations washighest in Amerindian groups (2,85%, 5 haplotypes shared) versus urbanpopulation (0,6%, 2 haplotypes shared). Interestingly, shared haplotypes werenot observed between the different tribal groups. The results between andwithin urban and Amerindian groups are consistent with previous studies. Thepercentage of shared haplotypes within the Amerindian group could be explainedby a higher endogamous behavior that characterizes these isolated and marginalpopulations. Development of local RM-YSTR reference databases is recommendedwhen forensic evidentiary material samples might be obtained from isolatedgroups.