INVESTIGADORES
ALONSO Daniel Fernando
artículos
Título:
In vitro and in vivo evaluation of desmopressin-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles for its potential use in cancer treatment
Autor/es:
CHEVALIER, MERARI T.; GARONA, JUAN; SOBOL, NATASHA T.; FARINA, HERNAN G.; ALONSO, DANIEL F.; ÁLVAREZ, VERA A.
Revista:
NANOMEDICINE
Editorial:
FUTURE MEDICINE LTD
Referencias:
Año: 2018 vol. 13 p. 2835 - 2849
ISSN:
1743-5889
Resumen:
Aim: To develop and characterize the antitumor activity of poly(D,L-lactic-co-glycolic acid) nanoparticles loaded with hemostatic and anticancer drug desmopressin (dDAVP). Materials & methods: After full physicochemical characterization, anticancer activity of dDAVP-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles (NPdDAVP) was evaluated in vitro and in vivo on a highly aggressive breast cancer model. Results: After efficiently loading desmopressin in poly(D,L-lactic-co-glycolic acid) matrix, NPdDAVP exhibited suitable physicochemical characteristics for biomedical applications. NPdDAVP displayed a potent cytostatic effect in vitro, inhibiting tumor cell proliferation and colony forming ability. Moreover, intravenous treatment using nanoparticulated-dDAVP inhibited tumor progression and prolonged survival in animals bearing rapidly-growing mammary tumors. Conclusion: Within the framework of promising dDAVP repurposing studies, these findings support further preclinical development of the NPdDAVP for the management of highly aggressive cancer.
