INVESTIGADORES
ALONSO Daniel Fernando
artículos
Título:
Peri-operative biology in primary breast cancer: selective targeting of vasopressin type 2 receptor using desmopressin as a novel therapeutic approach
Autor/es:
GARONA J; ALONSO DF
Revista:
BREAST CANCER RESEARCH AND TREATMENT
Editorial:
SPRINGER
Referencias:
Año: 2016 vol. 158 p. 597 - 599
ISSN:
0167-6806
Resumen:
In breast cancer patients, surgical excision of the primary tumor is commonly the first step toward long-term control of disease progression. However, recent evidence suggests that surgery may also promote metastatic relapse through different deleterious mechanisms, including, but not limited to, tumor cell shedding, immunosuppression, neuroendocrine perturbations, increased production of growth factors, and proangiogenic signaling. In this regard, the perioperative timeframe represents an underexploited window of opportunity that could be targeted in order to modulate tumor-host interactions and minimize the risk of both local and metastatic recurrence.